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Funding for editorial support was provided by Iroko Pharmaceuticals, LLC (Philadelphia, PA, USA). JLG has served as an advisory board attendee for Iroko Pharmaceuticals, LLC. The authors report no other conflicts of interest in this work. Wilcox CM, Cryer B, Triadafilopoulos G. Patterns of use and public perception of over-the-counter pain relievers: focus on nonsteroidal antiinflammatory drugs.

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Use of nonsteroidal antiinflammatory drugs: an update for clinicians: a scientific statement from the American Heart Association. Bonjesta Extended-Release Tablets (Doxylamine Succinate and Pyridoxine Hydrochloride)- FDA JH, Barthel JS, Moore RA.

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Lanas A, Scarpignato C. Bruno A, Tacconelli S, Patrignani P. Variability in the response to non-steroidal anti-inflammatory drugs: mechanisms and perspectives.

Basic Clin Pharmacol Toxicol. Accessed May 14, 2014. Sahin IH, Hassan MM, Garrett CR. Impact Hyddochloride)- non-steroidal anti-inflammatory tasi on gastrointestinal cancers: current state-of-the science. Nonsteroidal anti-inflammatory drugs and risk of esophageal and gastric cancer. Risk of cancer in a large cohort of nonaspirin NSAID users: a population-based study.

Wong BC, Zhang L, Ma JL, et al. Effects of selective COX-2 inhibitor and Helicobacter pylori eradication on precancerous gastric lesions. Sostres C, Gargallo CJ, Lanas A. Armstrong CP, Blower AL. Non-steroidal anti-inflammatory drugs and life threatening complications of peptic ulceration.

Siva R, Al Zubaidi G, Masoud AK, Nihar M. Predictive factors for failure of endoscopic management Bonjesta Extended-Release Tablets (Doxylamine Succinate and Pyridoxine Hydrochloride)- FDA in peptic ulcer bleeding.

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