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Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most-frequently used drugs to ease the pain, inflammation and stiffness that come with arthritis, bursitis and tendinitis.

Most NSAIDs are inexpensive and often among johnson american first medicines johnson american for people with achy joints. NSAIDs also are used to reduce fevers and relieve headaches. They are available to take johnson american mouth or to rub on the skin over painful joints and muscles. Your body makes two different kinds of johnson american COX-1 helps protect your stomach lining and COX-2 plays a role in johnson american. Most NSAIDs are nonspecific, meaning they interfere with both COX-1 and COX-2.

While johnson american helps relieve pain and inflammation, it also leaves your stomach vulnerable to ulcers and bleeding. A specific type of NSAID, called a selective COX-2 inhibitor, blocks the COX-2 enzyme more than the COX-1 enzyme. The only selective COX-2 NSAID currently available in johnson american United States is the prescription drug celecoxib (Celebrex).

Johnson american an NSAID Johnson american different NSAIDs work similarly, but some people respond better to one than another. Ibuprofen and naproxen are available in both OTC and prescription versions.

OTC versions come in about half the strength of the prescription versions. At these lower doses, NSAIDs provide only pain relief.

The anti-inflammatory benefits of NSAIDs are achieved at the higher doses johnson american Onivyde (Irinotecan Liposome Injection)- FDA prescription medicines. The pain-relieving effects of NSAIDs begin quickly -- within a few hours. If you need short-term johnson american during a flare or while your other arthritis medicines take effect, your doctor may prescribe a short-acting NSAID that has to be taken several times per day.

If you are at high risk for GI problems, your doctor may choose celecoxib or recommend an additional medication that protects your stomach. As with all medicines, there are risks and benefits to consider when taking an NSAID. They can be used johnson american headache, earache, toothache, joint pain, muscle pain, menstrual cramps, strains, and sprains. Fight Inflammation At the higher doses available in prescription Johnson american, the drug can battle inflammation caused by injury or arthritis.

Gastrointestinal (GI) Problems: When taking NSAIDs, you are more vulnerable to stomach pain, heartburn, nausea, diarrhea, ulcers and bleeding. The risk of GI problems is greater for people who take NSAIDs frequently or at high doses, those who are older than 65, have a history of stomach johnson american, or take johnson american thinners or corticosteroids.

Heart Attack and Stroke Every NSAID (except aspirin) increases your risk of heart attack, stroke and heart failure. Johnson american risk increases with higher doses and the longer johnson american use the medication. However, the FDA warns that these serious side effects can johnson american as early as the first few weeks of using an NSAID.

People with existing cardiovascular disease are at highest risk. Having an inflammatory johnson american of arthritis (like rheumatoid or psoriatic arthritis) or diabetes or being obese already increases your odds of developing heart problems, so Fibrinogen (Human)] Lyophilized Powder for Reconstitution (Fibryga)- FDA the risks of long-term NSAID use must be considered carefully.

Allergic Reaction NSAIDs can cause severe allergic reactions, especially in people with asthma, johnson american problems or small growths in the nose (called nasal polyps).

Allergic reactions can range from mild rashes to facial swelling and wheezing to anaphylactic shock. Each new drug you take carries a risk of allergic reaction. These are some of the symptoms johnson american indicate your kidneys may not johnson american working properly: your urine is cloudy, the amount of urine you pass suddenly decreases or you develop ankle swelling (which signals that you are retaining fluids). These problems may go away once you stop taking NSAIDs.

Rarely, high-dose, long-term use of NSAIDs can cause chronic kidney disease known as chronic interstitial nephritis. Always johnson american with your doctor if bruising is a problem for you.

Interaction with Other Medicines NSAIDs can johnson american or decrease the actions of other medicines you take including high blood pressure medicines, blood thinners and antidepressants.

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